Chemical characterization of the photodegradation products of midazolam complexes with randomly methylated-beta-cyclodextrin by HPLC and LC-MS/MS
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S Kustrin, M Lebete, ME Brown, D Morton, BD Glass
2016
opal.latrobe.edu.au
Midazolam, a potent anxiolytic drug with sedative properties, is susceptible to degradation by both light and hydrolysis in aqueous solution. When formulated as an intranasal product, it was found to be effective in achieving seizure control in epileptic patients. In order to deliver an adequate therapeutic dose to a patient, a nasal formulation requires the concentration of midazolam to be higher than its aqueous solubility. One way to increase midazolam solubility to a therapeutic concentration is complexation with randomly …
