期刊论文使用不同分析技术评估 Polatuzumab vedotin 和 Brentuximab vedotin 的稳定性复制

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HE Mohamed, MA Al-Ghobashy, SS Abbas…
… of Pharmaceutical and …, 2023
Elsevier
Antibody-drug conjugates (ADC) are considered to be fast-growing innovative biopharmaceuticals. The science used for conjugating potent cytotoxic payload to the targeted monoclonal antibody through a chemical linker has played a great value in the area of oncology treatment. In this study; Polatuzumab vedotin (POLA) and Brentuximab vedotin (SGN-35) were subjected to various stress conditions enclosing different pH, thermal stress, agitation, and successive cycles of freeze and thaw in order to produce potential …