期刊论文The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt.复制

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WH Rooks 2nd, PJ Maloney, LD Shott…
… and clinical research, 1985
europepmc.org
Ketorolac tromethamine [(+/-)-5 (benzoyl)-2, 3-dihydro-1N-pyrrolizine-1-carboxylic acid tris hydroxymethylaminomethane salt] is a highly potent member of a new class of compounds having analgesic and anti-inflammatory activity. When given orally in tests involving underlying inflammation it was a potent analgesic, whereas it was inactive in tests for narcotic activity. It was also highly active orally in rat models of acute and chronic inflammation and pyresis. These properties are mediated primarily via the compound's …