Innovative Strategies and Advances in Drug Delivery Systems to Address Poor Solubility: A Comprehensive Review
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H Bakrey, A Abdu, R Shivgotra, B Soni…
Current Drug …, 2025
benthamdirect.com
Poor solubility remains a significant obstacle in drug administration, adversely affecting the bioavailability and therapeutic efficacy of many drugs. It is also recognized as a primary factor contributing to issues with bioavailability, such as poor, inconsistent, limited, and highly variable bioavailability of marketed products. It is estimated that 40% of marketed drugs face bioavailability challenges primarily due to poor water solubility, and about 90% of pharmacological compounds exhibit poor water solubility in their early development stages …
