Potential efficacy of vosoritide for foramen magnum stenosis in a patient with achondroplasia.
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M Suzuki, K Sakamoto, Y Sakurai…
Pediatrics …, 2025
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The article focuses on the therapeutic effects of vosoritide, a C-type natriuretic peptide analog, in treating achondroplasia and its associated complications, particularly foramen magnum stenosis (FMS). Vosoritide targets the overactive fibroblast growth factor receptor 3 (FGFR3) pathway, promoting bone growth and improving skeletal development in children. A case report details the treatment of a 26-month-old boy with FMS, highlighting significant improvements in his condition after starting vosoritide at 6 months old, including a reduction …
