Experimental and Computational Approaches to the Study of Macrocycle Conformations in Solution
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J Schwochert, RS Lokey
2017
books.rsc.org
Macrocycles–in particular, cyclic peptides–have shown remarkable versatility as ligands against challenging therapeutic targets such as protein–protein interactions (PPIs). 1 Cyclization is an established method for improving potency in peptides, 2–4 and cyclization can dramatically improve the proteolytic stability of peptides. 4, 5 As the ability to understand and control physico-chemical properties in cyclic peptides has increased, so has interest in cyclic peptides as scaffolds for the design of next-generation therapeutics against …
