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Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165复制

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文献链接: https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00444复制

其他信息:

ST Wrobleski， R Moslin， S Lin， Y Zhang， S Spergel...
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…在小鼠 PK 研究中，相对于其吡啶对应物 43 的 Cmax（11 vs ...已经实现了良好的效力和选择性，具有出色的 PK 特性和......

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