期刊论文Safety, Tolerability and Pharmacokinetics of The Phosphodiesterase 3/4 (PDE3/4) Inhibitor TQC3721 Suspension for Inhalation in Healthy Adult Subjects复制

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Z Luo, L Yang, M Jiang, D Yu, W Li, W Li
2024
publications.ersnet.org
Background: TQC3721 is a PDE3/4 inhibitor, which can simultaneously achieve bronchial smooth muscle relaxation and anti-inflammatory effects. Objectives: To assess the safety, tolerability and pharmacokinetics of TQC3721 in healthy adult subjects. Methods: This randomized, double-blind, placebo-controlled, phase I study consisted of 6 single ascending-dose cohorts (SAD, 0.2 mg, 1mg, 3mg, 6mg, 12mg, 24mg), 1 multiple dose cohort (12mg once daily for 7 days) and 1 pulmonary deposition cohort (2-period crossover design in the …