Bioanalytical aspects in characterization and quantification of glucuronide conjugates in various biological matrices
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文献链接: https://www.eurekaselect.com/article/5918
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Abstract
The occurrence of phase II metabolism via conjugation pathway, has been observed for not only several endogenous molecules such as bilirubin, bile acids, steroid hormones (androgens and estrogens), retinoids, thyroid hormones, leukotriene B4, hydroxy metabolites of arachidonic and linoleic acids, several phenolic neurotransmitters etc. but also for a number of xenobiotics belonging to diversified chemical classes. Although topic of focus in this review is pertaining to glucuronidation, other conjugation phase II reactions are known to occur via sulfation, acetylation, methylation or simply via direct addition of glycine or glutathione adducts. The review covers the importance of glucuronidation while accounting for various types of known glucuronidation reactions. The formation of acyl glucuronides and the liability of acyl glucuronides to form chemically reactive species via acyl migration mechanism are also covered in this review. A concise review of the literature on bioana
