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Differential effects of morphine and non-steroidal anti-inflammatory drugs on somatic and visceral pain in rats复制

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H Ohmori, H Iwasaki, K Omote, I Kobayashi…
Masui. The Japanese …, 1994
europepmc.org
We studied the differential effects of morphine and non-steroidal anti-inflammatory drug (NSAIDs) on behavioral responses to tail-flick (TF) and colorectal distension (CD) in rats. Animals were randomly divided into three groups; morphine groups (4 mg. kg-1), flurbiprofen axetil groups (30 mg. kg-1) and aspirin DL-lysin groups (100 mg. kg-1). After determining control TF and CD values, animals received each analgesic intraperitoneally, and each procedure was repeated every 10 minutes for 30 or 40 minutes. NSAIDs produced …

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