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Post-marketing safety surveillance of the novel muscarinic antipsychotic Xanomeline-Trospium for schizophrenia: A comparative disproportionality analysis against …复制

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Y Zeng, X Wang, H Wu, X Tan, R Wang, Y Liu…
Psychiatry Research, 2026
Elsevier
Objective: To characterize the real-world post-marketing safety reporting profile and adverse event (AE) signals of Xanomeline-Trospium, a novel dual M1/M4 muscarinic antipsychotic for schizophrenia. Methods: FAERS data from 2024Q4 to 2025Q4 were retrospectively analyzed. Reports listing Xanomeline-Trospium as the primary suspected drug were extracted. Signals were detected using four algorithms: ROR, PRR, BCPNN, and MGPS. Additional analyses included Weibull time-to-onset modeling, exploratory comparison with …

上一篇：Real-world use of xanomeline/trospium chloride in a large academic healthcare system in the first year following FDA approval

下一篇：A real-world pharmacovigilance study of Xanomeline-Trospium events in the FDA adverse event reporting system (FAERS)

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