Determination of deuterium incorporation of new drug donafenib tosilate by two methods of LC-MS with natural isotope abundance correction and 1H NMR relative …
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DOI:
文献链接: http://dx.doi.org/10.16438/j.0513-4870.2023-0161
其他信息:
Y HUANG, Y WU, X CHENG, Q XU
Yao Xue Xue Bao, 2023
pesquisa.bvsalud.org
An LC-MS method with natural isotope abundance correction and a 1H NMR relative quantitative method were established to determine the deuterium incorporation of donafenib tosilate, a new deuterated drug molecule. First, the peak areas of isotopic impurities (non-deuterated and incompletely deuterated impurities) and deuterated drug were recorded through the single ion monitoring (SIM) mode of the established LC-MS method and then corrected in terms of the natural isotope abundance offered by ChemDraw soft, removing the …
