Angiopoietin-like protein Inhibitors: Promising Prospects for the Treatment of Familial Hypercholesterolemia and Atherogenic Dyslipidemia
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F Vahdat-Lasemi, L Farhoudi, SM Hosseinikhah…
Atherosclerosis, 2025
Elsevier
Background and aims This review examines the physiological functions of Angiopoietin-like proteins (ANGPTLs) in lipid metabolism and the epidemiology of atherosclerotic cardiovascular disease (ASCVD), while discussing their potential as therapies for dyslipidemias. Methods A review of contemporary literature on ANGPTLs was conducted. Results ANGPTLs comprise eight secreted proteins that share structural similarities with the angiopoietin family and serve as key regulators of various physiological and biochemical …
