Annulative Editing of Peptide Side Chains: N-Pyridination of Lysine via Chichibabin Pyridine Synthesis in Hexafluoroisopropanol
1. 当前求助状态已完结, 请及时下载应助文件
2. 系统将在 2025-06-10 14:45:13 删除文件
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
S Cai, C Wu, Z Zhang, X Chu, X Sun, S Jiang…
Organic …, 2025
ACS Publications
Modifying the lysine side chain through N-heteroaryl annulation offers a unique opportunity to tailor or edit the structure and properties of the parent peptides. Here, we report two new applications of the Chichibabin pyridine synthesis for lysine-specific peptide modification under mild conditions, employing two distinct classes of aldehyde reagents. Reactions with 2-arylacetaldehydes afforded symmetrical 3, 5-diarylpyridinium products via an abnormal Chichibabin pathway, whereas reactions with 2-hydroxyacetaldehyde yielded …
