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Remibrutinib, a Novel Bruton's Tyrosine Kinase Inhibitor, Exhibits Improved Target Selectivity and Potency In Vitro (P8-3.003)复制

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B Kieseier, B Cenni, R Pulz, D Angst, D Eichlisberger…
Neurology, 2023
neurology.org
… blood; the IC50 at 1 hour was 21 nM for remibrutinib, 508 nM … B-cell inhibition; the IC 50 was
18 nM for remibrutinib, 320 nM … B-cell inhibition by remibrutinib (covalent) was not sensitive …

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