Novel controlled metabolic accelerator for obesity-related HFpEF: the HuMAIN-HFpEF randomized clinical trial
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A Pandey, GD Lewis, BA Borlaug, SJ Shah…
JAMA …, 2025
jamanetwork.com
Importance Excess body fat plays a pivotal role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). HU6 is a novel, controlled metabolic accelerator that enhances mitochondrial uncoupling resulting in increased metabolism and fat-specific weight loss. Objective To assess efficacy and safety of HU6 in reducing body weight, improving peak volume of oxygen consumption (VO 2) and body composition among patients with obesity-related HFpEF. Design, Setting, and Participants The Exploratory …
