Cyclosporine pharmacokinetics in rats and interspecies comparison in dogs, rabbits, rats, and humans
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/2906601
其他信息:
PMID: 2906601
作者: L Sangalli; A Bortolotti; L Jiritano; M Bonati; L Sangalli; ...
摘要: The pharmacokinetics of cyclosporine, a potent immunosuppressive agent, are described for rats given 5 mg/kg iv, measuring blood concentrations by a specific HPLC method. Cyclosporine followed first-order kinetics and blood concentrations vs. time data were adequately described by a three-compartment open model system. The mean half-life of the lambda 1 phase was 0.11 hr, that of the lambda 2 phase was 1.82 hr, and the half-life of the estimated lambda 3 phase was 23.79 hr. The mean apparent vol...
