Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch
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W Lin, X Jia, X Shi, Q He, P Zhang, X Zhang, L Zhang…
Science, 2025
science.org
Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell and spatial transcriptomic analyses of rabbits and mice recovering from pinna damage. Insufficient retinoic acid (RA) production, caused by the deficiency of rate-limiting enzyme Aldh1a2 and boosted RA degradation, was responsible for the failure of mouse pinna regeneration. Switching on Aldh1a2 or RA supplementation reactivated …
