Ultra-Dilute Developability Analysis of Antibody Self-Association and Non-Specific Binding
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NY Kwon, M Karadag, PM Tessier
Antibody Engineering: Methods and …, 2026
Springer
Early-stage screening of antibody developability properties is important for identifying monoclonal antibody (mAb) candidates with favorable biophysical properties in addition to potent biological activities. Nevertheless, this process is challenging given the large numbers of mAb candidates, as well as their low quantities, concentrations, and purities. Here, we report methods for assessing the developability of mAbs in terms of their levels of self-association and non-specific binding at ultra-dilute concentrations (~ 0.01–0.05 mg/ml) …
