期刊论文Penetration and permeation into human skin of fusidic acid in different galenical formulation复制

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文献链接: https://pubmed.ncbi.nlm.nih.gov/3415719复制

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PMID: 3415719
作者: G Stüttgen; E Bauer; G Stüttgen; G Stüttgen; E Bauer
摘要: The penetration into the horny layer and permeation through the skin of fusidic acid, incorporated in different bases, e.g., cream, ointment and a gel (Fucidine), was investigated in vitro in a penetration chamber, using human skin. Whereas the horny layer offers a marked barrier to penetration in normal skin, this barrier can be greatly reduced by damaging the horny layer by adhesive tape stripping. Fusidic acid showed penetration into the different layers of skin which was related to the durat...