Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model
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DOI:
文献链接: https://onlinelibrary.wiley.com/doi/abs/10.1002/1531-8249(200006)47:6%3C739::AID-ANA6%3E3.0.CO;2-8
其他信息:
DM Holtzman, AM Fagan, B Mackey…
Annals of Neurology …, 2000
Wiley Online Library
The ε4 allele of apolipoprotein E (ApoE) is an important genetic risk factor for Alzheimer's disease (AD). Increasing evidence suggests that this association may be linked to the ability of ApoE to interact with the amyloid‐β (Aβ) peptide and influence its concentration and structure. To determine the effect of ApoE on Aβ and other AD pathology in vivo, we used APPsw transgenic mice and ApoE knockout (−/−) mice to generate APPsw animals that carried two (ApoE+/+), one (ApoE+/−), or no copies (ApoE−/−) of the normal mouse ApoE …
