Uric acid promotes dietary lipid absorption through microbiome and metabolomic remodeling via a liver-gut endocrine axis
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DOI:
文献链接: https://www.cell.com/cell-host-microbe/abstract/S1931-3128(26)00181-2
其他信息:
C Tian, X Guo, D Wang, Q Chen, H Shen, X Li, C Liu…
Cell Host & Microbe, 2026
cell.com
Hyperuricemia closely correlates with obesity, yet high uric acid (UA) is largely viewed as a consequence or biomarker of obesity rather than a causal driver. Integrating human clinical analyses with animal studies, we redefine UA as a liver-derived endocrine regulator that drives obesity by modulating gut ecology. UA remodels the gut microbiota, selectively depleting Lactobacillus johnsonii by disrupting peptidoglycan synthesis. This depletion reduces microbial phenyllactic acid (PLA)—a metabolite produced by L. johnsonii lactate …
