Review on sample preparation methods for oligonucleotides analysis by liquid chromatography
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Ł Nuckowski, A Kaczmarkiewicz…
Journal of Chromatography …, 2018
Elsevier
Antisense oligonucleotides have been successfully investigated for the treatment of different types of diseases. Detection and determination of antisense oligonucleotides and their metabolites are necessary for drug development and evaluation. This review focuses mainly on the first step of the analysis of oligonucleotides ie the sample preparation stage, and in particular on the techniques used for liquid chromatography and liquid chromatography coupled with mass spectrometry. Exceptional sample preparation techniques are required …
