Modular Ipso/Ortho Difunctionalization of 3-Iodochromones Enabled by Palladium/Norbornene Catalysis for Stereoselective Synthesis of Chromone C-Glycosides
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NS Chauhan, S Dubey, R Kant…
The Journal of Organic …, 2026
ACS Publications
We report a palladium-catalyzed Catellani-type ortho-C–H glycosylation strategy that enables modular ipso/ortho difunctionalization of 3-iodochromones, leading to highly functionalized α-C-chromone glycosides. Notable highlights include the use of ipso-Heck and Sonogashira couplings as flexible termination steps, along with a broad substrate scope, good chemoselectivity, step-economy, and scalability. In addition, our study presents a novel library of 2,3-difunctionalized chromone C-glycoside molecular scaffolds, offering significant potential for future drug discovery applications.ACS Publications展开收起保存 引用 相关文章 所有 2 个版本
