Modular Ipso/Ortho Difunctionalization of 3-Iodochromones Enabled by Palladium/Norbornene Catalysis for Stereoselective Synthesis of Chromone C-Glycosides
1. 系统已在2026-06-30 10:19:37对应助文件进行删除
2. 如有需要请重新发布求助信息
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
NS Chauhan, S Dubey, R Kant…
The Journal of Organic …, 2026
ACS Publications
We report a palladium-catalyzed Catellani-type ortho-C–H glycosylation strategy that enables modular ipso/ortho difunctionalization of 3-iodochromones, leading to highly functionalized α-C-chromone glycosides. Notable highlights include the use of ipso-Heck and Sonogashira couplings as flexible termination steps, along with a broad substrate scope, good chemoselectivity, step-economy, and scalability. In addition, our study presents a novel library of 2,3-difunctionalized chromone C-glycoside molecular scaffolds, offering significant potential for future drug discovery applications.ACS Publications展开收起保存 引用 相关文章 所有 2 个版本
