期刊论文Pharmacokinetics of isosorbide-5-mononitrate after oral and intravenous administration in patients with liver cirrhosis: first results复制

DOI:复制

文献链接: https://pubmed.ncbi.nlm.nih.gov/6666228复制

其他信息:

PMID: 6666228
作者: H C Steudel; M Volkenandt; A T Steudel; H C Steudel; H C Steudel; ...
摘要: The pharmacokinetics and bioavailability of IS-5-MN after single-dose oral and intravenous application were investigated over 24 h in three patients with liver cirrhosis and compared with normal subjects. The analysis of IS-5-MN in plasma was carried out using a gas-chromatographic method with electron capture detection. A two-compartment open model was taken as a basis for the calculations of the plasma concentration curves and the pharmacokinetic parameters. First results show that plasma conc...