Pharmacokinetics of isosorbide-5-mononitrate after oral and intravenous administration in patients with liver cirrhosis: first results
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/6666228
其他信息:
PMID: 6666228
作者: H C Steudel; M Volkenandt; A T Steudel; H C Steudel; H C Steudel; ...
摘要: The pharmacokinetics and bioavailability of IS-5-MN after single-dose oral and intravenous application were investigated over 24 h in three patients with liver cirrhosis and compared with normal subjects. The analysis of IS-5-MN in plasma was carried out using a gas-chromatographic method with electron capture detection. A two-compartment open model was taken as a basis for the calculations of the plasma concentration curves and the pharmacokinetic parameters. First results show that plasma conc...
