Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/8667222
其他信息:
PMID: 8667222
作者: A Kakee; T Terasaki; Y Sugiyama; A Kakee; A Kakee; ...
摘要: A brain efflux index method has been developed to characterize an efflux transport system for substrates from the cerebrum to the circulating blood across the blood-brain barrier. The brain efflux index value is defined as the relative amount of test drug effluxed from cerebrum compared with that of a reference compound, [14C]carboxylinulin, which has limited blood-brain barrier permeability. Microinjection of 0.2, 0.5 or 1.0 microliter into the parietal cortex area 2 region was found to be an a...
