Triply convergent Ni-electrocatalytic assembly of 1, 1-diaryl cyclobutanes, azetidines and oxetanes
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DOI:
文献链接: https://cwres.ncu.edu.cn/s/gov/nih/nlm/ncbi/pubmed/G.https/41219521/?;x-chain-id=b0plufu5ebr4
其他信息:
L Massaro, P Neigenfind, A Feng, G Kuehn…
Nature Chemistry, 2025
nature.com
The pursuit of increasingly complex, three-dimensional molecules is pushing the boundaries of modern organic synthesis, particularly in drug discovery where rigid, saturated scaffolds such as cyclobutanes, azetidines and oxetanes are in high demand. Here we outline a modular, scalable, chemoselective approach to solve this problem using simple α-bromoacids and aryl halides as intuitive starting materials. As demonstrated herein, a sequential series of nickel-electrocatalytic cross-couplings can be enlisted to enable rapid …
