LDLR-mediated targeting and productive uptake of siRNA-peptide ligand conjugates in vitro and in vivo
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B Broc, K Varini, R Sonnette, B Pecqueux, F Benoist…
Pharmaceutics, 2024
mdpi.com
Small RNA molecules such as microRNA and small interfering RNA (siRNA) have become promising therapeutic agents because of their specificity and their potential to modulate gene expression. Any gene of interest can be potentially up-or down-regulated, making RNA-based technology the healthcare breakthrough of our era. However, the functional and specific delivery of siRNAs into tissues of interest and into the cytosol of target cells remains highly challenging, mainly due to the lack of efficient and selective delivery systems. Among …
