Regio‐and Chemoselective C H Chlorination/Bromination of Electron‐Deficient Arenes by Weak Coordination and Study of Relative Directing‐Group Abilities
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X Sun, G Shan, Y Sun, Y Rao
Angewandte Chemie, 2013
academia.edu
Aromatic chlorides are an important class of compounds utilized in drug and natural product syntheses.[1] Today, about 85% of all pharmaceuticals contain or are manufactured using chlorine. By far the most prevalent strategies for preparing aromatic chlorides are still the classic directed ortho lithiation, eletrophilic aromatic substitution, and Sandmeyer reaction. However, these methods usually suffer from one or more limitations including poor regioselectivity, low yield, harsh reaction conditions, long reaction time, and tedious reaction …
