Monomeric Fc fusions: impact on pharmacokinetic and biological activity of protein therapeutics
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JA Dumont, SC Low, RT Peters, AJ Bitonti
BioDrugs, 2006
Springer
The delivery of therapeutic proteins by noninvasive routes of administration has been a challenging goal, hence current modes of delivery generally require injections. However, we have recently shown that a naturally occurring receptor, the neonatal Fc receptor (FcRn) can be utilized to carry aerosolized therapeutic proteins conjugated to a portion of its respective ligand (Fc domain of immunoglobulin G) across epithelial cells of the lung to effectively deliver biologically active molecules to the bloodstream. First-generation dimeric Fc fusion …
