Kv1. 3 knockdown attenuates alcohol-related liver injury in mice through induction of tryptamine
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H Wang, G Xia, T Ke, X Chen, W Zhen, Y Tian…
Acta Pharmacologica …, 2025
nature.com
Alcohol-related liver disease (ALD) refers to a spectrum of liver diseases caused by chronic or acute excessive alcohol consumption. Excess alcohol consumption and dysregulated immunometabolism are the major contributors to the disease progression. The pathogenesis of ALD remains unclear with macrophage activity playing a key role in disease development. Kv1. 3 potassium channel is essential for the regulation of macrophage function. In this study, we investigated whether Kv1. 3 channels influenced the progression of ALD by …
