Aztreonam for injection (lyophilized): development of an automated solution batching process utilizing volumetric powder feeders
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/2600735
其他信息:
PMID: 2600735
作者: K Weijer; R Augustine; C Carleton; T Haby; E Kuspiel; ...
摘要: As part of a commitment to fully automate the manufacture of a lyophilized dosage form of Azactam (Aztreonam for Injection), an automated solution batching procedure was developed. The lyophilization process requires solution batching of Aztreonam and L-arginine, the two constituents of the product. To avoid preblending of aztreonam and L-arginine prior to dissolution, a batching process was developed which makes use of two separate volumetric powder feeders. In conjunction with a feedback pH co...
