Contrasting roles for the GLP-1R and GIPR in a model of diet-induced obesity
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J Gao, S Cree, S Ham, C Nowell…
Journal of …, 2025
jme.bioscientifica.com
The GLP-1R (glucagon-like peptide-1 receptor) and GIPR (glucose-dependent insulinotropic polypeptide receptor) are important incretin receptors that are therapeutic targets for the treatment of type 2 diabetes and obesity. This study extensively characterised the metabolic phenotype of mice with global deletion of either the GLP-1R or GIPR side-by-side under identical conditions. Age-matched male wild-type (WT) C57Bl6NTac, GLP-1RKO or GIPRKO mice were placed on a high-fat or chow diet for 12 weeks and a range of in vivo …
