Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain
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DOI: doi: 10.1016/j.bmc.2022.116743
文献链接: https://linkinghub.elsevier.com/retrieve/pii/S0968089622001353
其他信息:
出版社: Elsevier BV
作者: Meena V. Patel; Hillary M. Peltier; Mark A. Matulenko; John R. Koenig; Marc J. C. Scanio; Rebecca J. Gum; Odile F. El-Kouhen; Meagan M. Fricano; Greta L. Lundgaard; Torben Neelands; Xu-Feng Zhang; Cenchen Zhan; Madhavi Pai; Nayereh Ghoreishi-Haack; Thomas Hudzik; Gary Gintant; Ruth Martin; Steve McGaraughty; Jun Xu; Daniel Bow; John C. Kalvass; Philip R. Kym; David A. DeGoey; Michael E. Kort
