FRI0272 Pharmacodynamic effects of atacicept treatment in a cynomolgus monkey klh antigen challenge model
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E Samy, A Bender, Y Wu, V Castagna, E Bertotti…
Annals of the Rheumatic …, 2018
Elsevier
Background Atacicept is an antagonist of the B cell regulatory factors BLyS (B lymphocyte stimulator) and APRIL (a proliferation inducing ligand). It is capable of binding to all known conformations of BLyS and APRIL and is thus expected to modulate the maturation, differentiation, and effector function of B cells. We aimed to define the relationship between atacicept drug exposure and pharmacodynamic (PD) effects in vivo. Here, we report results of our study examining the effects of atacicept on the immune response in a keyhole limpet …
