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Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma复制

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文献链接: https://pubs.acs.org/jmcmar/article-abstract/63/13/6648/1305898/Discovery-of-CRBN-E3-Ligase-Modulator-CC-92480-for?redirectedFrom=fulltext复制

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JD Hansen，M Correa，MA Nagy......
《医学杂志》，2020年
ACS出版
许多多发性骨髓瘤（MM）患者最初对现代联合治疗方案有反应，包括免疫调节剂（来那度胺和波马度胺）和蛋白酶体抑制剂。然而，有些患者缺乏初期治疗反应（即难治性），尽管近年来多发性骨髓瘤患者的平均生存率翻了一番多，但大多数患者最终仍会复发。为满足这一需求，我们探索了新型脑红蛋白E3连接酶调节剂（CELMoDs）在治疗中的潜力......

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