期刊论文Oseltamivir oral suspension and capsules are bioequivalent for the active metabolite in healthy adult volunteers.复制

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S Lennon, J Barrett, C Kirkpatrick…
International journal of …, 2009
europepmc.org
Aims The objective of this study was to assess the relative bioavailability of oseltamivir carboxylate (active metabolite) following oral administration of the market suspension, the clinical trial suspension and the market capsule formulations of oseltamivir (prodrug) in healthy subjects. Methods In this single-center, open-label, three-period crossover study, 24 healthy adult volunteers were randomized to receive one dose (150 mg oseltamivir) of each of the three formulations (market suspension, clinical trial suspension, market capsule …