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肿瘤抗体药物偶联物的研发进展和挑战复制

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李博乐， 冯红蕾， 魏枫， 孟帅， 吴春暖， 张洁， 任秀宝
中国肿瘤临床, 2022
cjco.cn
… 本文就ADC 药物的靶 点,抗体,载荷毒素,连接子及偶联方式的… 4.2 不可裂解的连接子 连接子部分不被裂解或酶解,药物内化后… 与马来酰亚胺的连接子反应,产生DAR 值为2,4, 6,8 的ADC 药物[25].…

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