Chronic kidney disease in patients with heart failure with a preserved ejection fraction: the underlying role of visceral adiposity
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M Packer, J Testani, J Butler, F Zannad, CSP Lam…
JACC, 2025
Elsevier
It has been hypothesized that an impairment of kidney function may contribute to the development of heart failure with a preserved ejection fraction (HFpEF). However, the conventional threshold for the identification of intrinsic renal disease in HFpEF (estimated glomerular filtration rate [eGFR]< 60 mL/min/1.73 m 2) does not consider age-related physiological changes. When adjusted for age, the appropriate threshold is< 45 mL/min/1.73 m 2, leading to a prevalence of impaired glomerular function of≈ 15% to 25% among …
