Outcome correlates of approved CD19-targeted CAR T cells for large B cell lymphoma
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TJ Bock, CK Colonne, S Fiorenza…
Nature Reviews Clinical …, 2025
nature.com
CD19-targeted chimeric antigen receptor (CAR) T cells have provided a breakthrough in the treatment of patients with relapsed and/or refractory large B cell lymphoma (LBCL). Currently, three CD19-targeted CAR T cell products are approved by the FDA and various other regulators for the treatment of patients with LBCL: axicabtagene ciloleucel, tisagenlecleucel and lisocabtagene maraleucel. Response rates following infusion of these CD19-targeted CAR T cells have been promising; however, approximately half of treated …
