Human UGT2B7 catalyzes morphine glucuronidation
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/9010622
其他信息:
PMID: 9010622
作者: B L Coffman; G R Rios; C D King; T R Tephly; B L Coffman; ...
摘要: A human UDP-glucuronosyltransferase (UGT) catalyzing the glucuronidation of morphine has been identified. A full length cDNA was isolated from a human liver cDNA library and found to be identical to the UGT2B7 form having a tyrosine at position 288. This cDNA was transfected into HK 293 cells, and stable expression was achieved. Cell homogenates and membrane preparations from HK 293 cells expressing UGT2B7 catalyzed the glucuronidation of morphine and other clinically significant opioid agonists...
