Efimosfermin alfa (BOS-580), a long-acting FGF21 analogue, in participants with phenotypic metabolic dysfunction-associated steatohepatitis: a multicentre …
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DOI:
文献链接: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00067-6/abstract
其他信息:
R Loomba, KV Kowdley, J Rodriguez…
The Lancet …, 2025
thelancet.com
Background Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive disease characterised by steatosis, inflammation, and liver fibrosis. Efimosfermin alfa (efimosfermin, formerly BOS-580) is a long-acting, engineered variant of FGF21 designed to have a prolonged half-life. We aimed to assess the safety and tolerability of multiple efimosfermin doses and dosing regimens compared with placebo and to evaluate exploratory biomarkers of efficacy in participants with phenotypic MASH. Methods This …
