Guanylyl Cyclase 2C–Targeted Chimeric Antigen Receptor T-Cell Therapy in Patients With Metastatic Colorectal Cancer
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C Qi, C Liu, J Gong, X Wang, Z Wang, T Xu…
Journal of Clinical …, 2026
ascopubs.org
PURPOSE The clinical efficacies of third-or later-line therapies for metastatic colorectal cancer (CRC) are extremely limited. The purpose of this study was to evaluate the safety and efficacy of a chimeric antigen receptor T (CAR T) cell targeting guanylyl cyclase 2C (GUCY2C) that was steadily expressed in all stages of CRC in a phase I study. PATIENTS AND METHODS This was an open-label, single-center, phase I study, consisting of a 3 3 pattern dose-escalation phase and a dose-expansion investigation. Tumor tissues were …
