Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/10640517
其他信息:
PMID: 10640517
作者: W Zhu; L Song; H Zhang; L Matoney; E LeCluyse; ...
摘要: Carboxylesterases play important roles in the metabolism of endogenous and foreign compounds, therefore, xenobiotic regulation of carboxylesterase gene expression has both physiological and pharmacological significance. We previously reported that liver microsomal esterase activity was significantly decreased in rats treated with dexamethasone accompanied by a decrease in immunoreactive proteins of rat hydrolase A, B, and C. The aim of this study was to determine whether the suppressed expressio...
