期刊论文URC102, a potent and selective inhibitor of hURAT1, reduced serum uric acid in healthy volunteers复制

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HA Lee, KS Yu, SI Park, S Yoon, M Onohara…
…, 2019
academic.oup.com
Objective URC102, a novel and potent inhibitor of human uric acid transporter 1 (hURAT1), is currently under clinical development to treat patients with gout. We performed a randomized, double-blind, placebo-controlled, phase I study to evaluate the safety, tolerability, pharmacodynamic, and pharmacokinetic profiles of URC102 after single and multiple oral administration in healthy male subjects. Methods Thirty-one Koreans and 23 Caucasians received a single dose of URC102 at 1–30 mg and 1–10 mg, respectively, while …