期刊论文Double-blind comparison of standard Sinemet and Sinemet CR in patients with mild-to-moderate Parkinson's disease复制

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文献链接: https://pubmed.ncbi.nlm.nih.gov/2685655复制

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PMID: 2685655
作者: R G Feldman; P A Mosbach; M R Kelly; C A Thomas; M H Saint Hilaire; ...
摘要: The combination of carbidopa and levodopa (Sinemet) is a highly effective treatment for the symptoms of Parkinson's disease. However, side effects, such as abnormal involuntary movements, fluctuations in motor performance, and "wearing off" phenomena limit its long-term usefulness in some patients. Open-label studies show that controlled-release Sinemet CR is effective in reducing motor fluctuations. This report discusses the results of a 14-week double-blind crossover study comparing the effica...