Panoramic characterization and structure–activity relationship of astragalus polysaccharides: Modulating M2-to-M1 repolarization via the TLR4–NF-κB pathway
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M Wang, W Sun, Y Ma, X Chen, K Zhang, J Gao…
Carbohydrate …, 2026
Elsevier
Over 30 Astragalus polysaccharides have been reported, yet most studies focus on individual structures with inconsistent findings, which hinders structure–activity relationship (SAR) analysis and the association between efficacy and active substances. Here, Astragalus polysaccharides were characterized at three levels: crude polysaccharides (ARCP), neutral (ARN) and acidic (ARA) fractions, and purified homogeneous polysaccharides (ARNPs and ARAPs). Their M2-to-M1 repolarization effects, mechanisms …
