Lipoprotein‐Based Nanocatalyst Enables Targeted Treatment of APAP‐Induced Liver Injury via Enhanced Macropinocytosis
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Y Chen, G Jiang, Y Huang, S Song, H Fu…
Advanced …, 2025
Wiley Online Library
Drug‐induced liver injury (DILI), predominantly caused by acetaminophen (APAP) overdose, is characterized by excessive reactive oxygen species (ROS) production and subsequent hepatocyte necrosis. Although N‐acetylcysteine (NAC) remains the only approved treatment, its effectiveness is limited by a narrow therapeutic time window and reduced efficacy in advanced cases. To address these limitations, an innovative therapeutic approach is developed utilizing ceria's antioxidant properties. In this study, a reconstituted …
