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Comparison of uptake of CardioPET, a potential PET tracer for myocardial fatty acid utilization and BFPET, a possible PET blood flow marker in fed vs fasted mice复制

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E Carter, D Elmaleh, T Shoup, A Bonab, K Paul…
2011
jnm.snmjournals.org
1098 Objectives CardioPET (trans-9-[18F] fluoro-3, 4-methyleneheptadecanoic acid), a modified fatty acid closely resembling naturally-occurring free fatty acids, undergoes metabolic trapping at the first step of beta-oxidation in heart tissue. Previously we observed that fasting decreased cardiac uptake of CardioPET in mice. In the present study we compared cardiac uptake of CardioPET and BFPET (4-[18 F] fluorophenyltriphenylphosphonium, a PET blood flow marker, in fed and fasted mice …

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