Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/10411607
其他信息:
PMID: 10411607
作者: H E Shannon; J C Hart; F P Bymaster; D O Calligaro; N W DeLapp; ...
摘要: The purpose of our studies was to determine the effects of muscarinic receptor agonists on conditioned avoidance responding in the rat. Rats were trained to avoid or escape an electric shock delivered to the feet in a discrete trial procedure. The muscarinic receptor agonists pilocarpine and [2-ethyl-8-methyl-2,8-diazaspiro(4. 5)decane-1,3-dione] hydrochloride (RS86) and the cholinesterase inhibitor physostigmine all decreased the percentage of avoidance responses at doses that produced less tha...
